abstract：OBJECTIVE:To investigate the effect of angiotensin converting enzyme inhibition (ACE-I) or angiotensin receptor blockade (ARB), and their combination, on both diabetic autonomic neuropathy (DAN) and left ventricular (LV) diastolic dysfunction (LVDD) in asymptomatic patients with diabetes mellitus (DM). MATERIALS AND M...

journal_title：Journal of diabetes and its complications

authors： Didangelos TP,Arsos GA,Karamitsos DT,Athyros VG,Georga SD,Karatzas ND

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:This meta-analysis was conducted to assess the association between diabetes mellitus and periodontal diseases by comparing the extent and severity of periodontal diseases between diabetics and nondiabetics. METHODS:A literature search was performed using MEDLINE database for published studies from January 1...

journal_title：Journal of diabetes and its complications

authors： Khader YS,Dauod AS,El-Qaderi SS,Alkafajei A,Batayha WQ

更新日期：2006-01-01 00:00:00

abstract：:Hyperglycaemia increases inflammatory cytokine concentration in the blood. Elevated levels of interleukin-18 (IL-18), a cytokine belonging to the interleukin-1 (IL-1) family, were recently reported in patients with Type 2 diabetes mellitus (DM2) and nephropathy. The aim of the present work was an examination of IL-18 ...

journal_title：Journal of diabetes and its complications

authors： Skopiński P,Rogala E,Duda-Król B,Lipińska A,Sommer E,Chorostowska-Wynimko J,Szaflik J,Partyka I,Skopińska-Rózewska E

更新日期：2005-11-01 00:00:00

abstract：AIMS:The aim of this study was to investigate the association between Type 2 diabetes and community-acquired infections. METHODS:We recruited 68 patients (mean+/-S.D. age=64.9+/-9.1 years; 57.4% males) from a community-based cohort and their nondiabetic partners (age=63.8+/-9.9 years; mean relationship duration=37.3+/...

journal_title：Journal of diabetes and its complications

authors： Davis TM,Weerarathne T,Foong Y,Mason C,Davis WA

更新日期：2005-09-01 00:00:00

abstract：:Adrenomedullin (AM), an ubiquitous regulatory peptide with different actions, is known to be elevated in different clinical situations, including diabetes mellitus (DM), but its potential role in the pathogenesis of diabetic vascular complications is not clear. In the present study, we examined plasma total AM levels,...

journal_title：Journal of diabetes and its complications

authors： García-Unzueta MT,Berrazueta JR,Pesquera C,Obaya S,Fernández MD,Sedano C,Amado JA

更新日期：2005-05-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to compare the prevalence of diabetes-related comorbidities in Asian Americans to the prevalence in other racial and ethnic groups in the United States using data from the 2001 Behavioral Risk Factor Surveillance System (BRFSS). METHODS:The BRFSS is a population-based telephone surv...

journal_title：Journal of diabetes and its complications

authors： McNeely MJ,Boyko EJ

更新日期：2005-03-01 00:00:00

abstract：OBJECTIVE:To evaluate the effectiveness of the Semmes-Weinstein monofilament examination (SWME) for diabetic peripheral neuropathy (DPN) screening at an outpatient clinic. METHODS:Eighty-two type 2 diabetic outpatients were questioned about 13 subjective symptoms and tested for deep reflexes. They were examined using ...

journal_title：Journal of diabetes and its complications

authors： Kamei N,Yamane K,Nakanishi S,Yamashita Y,Tamura T,Ohshita K,Watanabe H,Fujikawa R,Okubo M,Kohno N

更新日期：2005-01-01 00:00:00

abstract：:People with Type 2 diabetes have bone mass alterations and may have a higher risk of hip fractures. Moreover, they have increased cardiovascular risk factors. The objective of this paper is to investigate the association among non-insulin-dependent diabetes, bone mineral density (BMD), and cardiovascular risk factors....

journal_title：Journal of diabetes and its complications

authors： Pérez-Castrillón JL,De Luis D,Martín-Escudero JC,Asensio T,del Amo R,Izaola O

更新日期：2004-11-01 00:00:00

abstract：:Carnitine is essential for the lipid and carbohydrate metabolism, and proper metabolic control in type 1 diabetes has potential impact on long-term complications. The plasma total, free, and acylcarnitine levels in 47 children and adolescents with type 1 diabetes were determined by a radioisotopic assay and compared t...

journal_title：Journal of diabetes and its complications

authors： Mamoulakis D,Galanakis E,Dionyssopoulou E,Evangeliou A,Sbyrakis S

更新日期：2004-09-01 00:00:00

abstract：:Although higher levels of hemoglobin A1c (HbA1c) and blood pressure precede the development of nephropathy in Type 1 diabetes (T1DM), the relationship between glycemic control and cardiovascular factors early in the course of diabetes is not clear. We conducted a retrospective study from clinic data for a 1-year perio...

journal_title：Journal of diabetes and its complications

authors： Torchinsky MY,Gomez R,Rao J,Vargas A,Mercante DE,Chalew SA

更新日期：2004-07-01 00:00:00

abstract：BACKGROUND:Altered platelet morphology and function have been reported in patients with diabetes mellitus. They are likely to be associated with the pathological processes and increased risk of vascular disease seen in these patients. We aimed to determine the mean platelet volume (MPV) in diabetics compared to nondiab...

journal_title：Journal of diabetes and its complications

authors： Hekimsoy Z,Payzin B,Ornek T,Kandoğan G

更新日期：2004-05-01 00:00:00

abstract：OBJECTIVE:The aims of this study were the following: (1). to determine the levels of endothelin-1(ET1), soluble adhesion molecules like intracellular adhesion molecule-1 (sICAM-1), and vascular cell adhesion molecule-1 (sVCAM-1) in different stages of glucose intolerance and to identify a suitable marker of endothelial...

journal_title：Journal of diabetes and its complications

authors： Viswanathan V,Snehalatha C,Nair MB,Ramachandran A

更新日期：2004-01-01 00:00:00

abstract：:Endothelin (ET)-1 has been implicated in the pathogenesis of diabetes, arteriosclerosis, and chronic renal failure. We studied whether low-density lipoprotein (LDL) apheresis alters plasma ET-1 levels in diabetic hemodialysis patients with arteriosclerosis obliterans (ASO). Plasma ET-1 levels were measured in 30 healt...

journal_title：Journal of diabetes and its complications

authors： Nakamura T,Ushiyama C,Osada S,Inoue T,Shimada N,Koide H

更新日期：2003-11-01 00:00:00

abstract：OBJECTIVE:Type 2 diabetes mellitus (DM-2) is an important cardiovascular risk factor, although hardly any data are available in our country. Therefore, we decided to study the incidence of cardiovascular disease (CVD) and the related variables with its appearance in a group of patients with DM-2. RESEARCH DESIGN AND M...

journal_title：Journal of diabetes and its complications

authors： Rius Riu F,Salinas Vert I,Lucas Martín A,Romero González R,Sanmartí Sala A

更新日期：2003-09-01 00:00:00

abstract：:Women with diabetes mellitus (DM) have urinary tract infection (UTI) more often than women without DM. It is unknown, however, what the prevalence and type of renal damage due to UTI is in these women. Therefore, in this study, we compared type 2 DM women with or without UTI history for the prevalence and type of rena...

journal_title：Journal of diabetes and its complications

authors： Wu HC,Chang CH,Lai MM,Lin CC,Lee CC,Kao A

更新日期：2003-09-01 00:00:00

abstract：:The objective of this study was to investigate the efficacy, tolerability, and safety of acarbose in the improvement of glycemic control in Asian patients with type 2 diabetes inadequately controlled by diet and sulfonylureas. A 24-week, double-blind, placebo-controlled multicenter group comparison study was conducted...

journal_title：Journal of diabetes and its complications

authors： Lin BJ,Wu HP,Huang HS,Juang JH,Sison A,bin Abdul Kadir DK,Cho CG,Sridama W,Writing Group for the Asian Study of Acarbose with Sulfonylureas.

更新日期：2003-07-01 00:00:00

abstract：:We compared the levels of microparticles, platelet activation markers, soluble cell adhesion molecules, soluble selectins, and antioxidized low-density lipoprotein (anti-Ox LDL) antibody between patients with hyperlipidemia and control subjects. Binding of anti-glycoprotein (GP) IIb/IIIa and anti-GPIb monoclonal antib...

journal_title：Journal of diabetes and its complications

authors： Nomura S,Kanazawa S,Fukuhara S

更新日期：2003-05-01 00:00:00

abstract：:This study was designed to determine the incidence and prevalence of amputations in diabetic Mexican American elders and to identify correlates of lower extremity amputations. Data for this study came from baseline and two follow-up interviews of the Hispanic Established Population for the Epidemiological Study of the...

journal_title：Journal of diabetes and its complications

authors： Otiniano ME,Du X,Ottenbacher K,Black SA,Markides KS

更新日期：2003-03-01 00:00:00

abstract：:Monocyte chemoattractant protein-1 (MCP-1), is a chemokine that mediates renal interstitial inflammation, tubular atrophy, and interstitial fibrosis by recruiting monocytes/macrophages into renal tubulointerstitium. Recent studies have demonstrated that protein overload in renal tubular cells up-regulates MCP-1 gene a...

journal_title：Journal of diabetes and its complications

authors： Morii T,Fujita H,Narita T,Shimotomai T,Fujishima H,Yoshioka N,Imai H,Kakei M,Ito S

更新日期：2003-01-01 00:00:00

abstract：:A few reports have suggested that angiotensin-converting enzyme inhibitors (ACE-I) have a beneficial effect on mild diabetic retinopathy (DR). This pilot study was carried out to determine if a small dose of an ACE-I would retard the progression of moderate to severe DR in normotensive Type 2 diabetic patients. Normot...

journal_title：Journal of diabetes and its complications

authors： Pradhan R,Fong D,March C,Jack R,Rezapour G,Norris K,Davidson MB

更新日期：2002-11-01 00:00:00

abstract：:To clarify the influence of blood glucose level or diabetes mellitus on serum KL-6, a mucin-like glycoprotein, concentrations, they were measured against 176 diabetic subjects, including receiving insulin (INS) group (n=54), oral antidiabetics (OAD) group (n=78), and diet and exercise (D&E) group (n=44). Serum KL-6 co...

journal_title：Journal of diabetes and its complications

authors： Takahashi T,Takamura K,Sakaue S,Ishii J,Yokouchi H,Nasuhara Y

更新日期：2002-09-01 00:00:00

abstract：:The importance of routine screening for microalbuminuria in patients with diabetes has gained widespread acceptance. Since shortened collection times and random urine sampling facilitate outpatient testing for patients, it is necessary to establish whether a recent fluid intake might alter test results. Specifically, ...

journal_title：Journal of diabetes and its complications

authors： Ravikovich E,Messersmith T,Mick G,McCormick K

更新日期：2002-07-01 00:00:00

abstract：:To clarify the relationship of the plasma brain natriuretic peptide (BNP) levels to diabetic complications, we studied plasma BNP levels in 100 normotensive diabetic patients without clinical cardiac disease and macroalbuminuria. The values of plasma BNP levels were not significantly different between patients with mi...

journal_title：Journal of diabetes and its complications

authors： Asakawa H,Fukui T,Tokunaga K,Kawakami F

更新日期：2002-05-01 00:00:00

abstract：STATEMENT OF THE PROBLEM:Medial arterial calcinosis (MAC) is associated with neuropathy, amputation, and mortality through an unknown mechanism. We hypothesized that MAC was a marker of autonomic neuropathy rather than a risk factor and that the outcomes were due to autonomic neuropathy. METHODS:All subjects in an ong...

journal_title：Journal of diabetes and its complications

authors： Mayfield JA,Caps MT,Boyko EJ,Ahroni JH,Smith DG

更新日期：2002-03-01 00:00:00

abstract：:We have previously reported that high glucose stimulates osteopontin (OPN) expression through protein kinase C-dependent pathway, as well as the hexosamine pathway, in cultured rat aortic smooth muscle cells (SMC). The finding prompted us to study in vivo expression of OPN in diabetes mellitus. In the present study, w...

journal_title：Journal of diabetes and its complications

authors： Mori S,Takemoto M,Yokote K,Asaumi S,Saito Y

更新日期：2002-01-01 00:00:00

abstract：:Type 2 diabetes results from the abnormal resistance of peripheral tissues to insulin and from the progressive insulin secretory failure of the pancreatic beta-cells. Treatment of type 2 diabetes has greatly improved due to the availability of new classes of oral antidiabetic drugs (OADs) and new insulin analogs. Thre...

journal_title：Journal of diabetes and its complications

authors： Rosak C

更新日期：2002-01-01 00:00:00

abstract：:To determine whether inflammatory cytokines are increased in proliferative diabetic retinopathy. We measured concentrations of interleukin-6, 8 (IL-6, 8) and tumor necrosis factor (TNF)-alpha by enzyme-linked immunosorbent assay (ELISA) in vitreous and serum from 47 patients with proliferative diabetic retinopathy and...

journal_title：Journal of diabetes and its complications

authors： Yuuki T,Kanda T,Kimura Y,Kotajima N,Tamura J,Kobayashi I,Kishi S

更新日期：2001-09-01 00:00:00

abstract：:To examine genetic polymorphism in the complete sequence of the Receptor of Advanced Glycation End products (RAGE) gene and its possible associations with diabetes-associated microvascular dermatoses (DAMD). Further, to analyze the distribution of individual genotype combinations on the particular polymorphic loci in ...

journal_title：Journal of diabetes and its complications

authors： Kanková K,Záhejský J,Márová I,Muzík J,Kuhrová V,Blazková M,Znojil V,Beránek M,Vácha J

更新日期：2001-07-01 00:00:00

abstract：:Diabetes is associated with a high level of mortality due to cardiovascular disease resulting from accelerated coronary artery atherosclerosis. A current focus for investigation of atherosclerotic mechanisms is the vascular endothelium since physical or functional injury may represent an initiating step for atherogene...

journal_title：Journal of diabetes and its complications

authors： de Dios ST,Hannan KM,Dilley RJ,Hill MA,Little PJ

更新日期：2001-05-01 00:00:00

abstract：:Leptin is considered to play an important role in the regulation of body weight and metabolism in obese individuals. However, the relationship of leptin with metabolic disorders or vascular complications in type 2 diabetic patients has yet to be elucidated. In this study, we investigated the association of leptin leve...

journal_title：Journal of diabetes and its complications

authors： Asakawa H,Tokunaga K,Kawakami F

更新日期：2001-03-01 00:00:00

abstract：:Hypomagnesemia is common in diabetic subjects, and is especially common in poorly controlled diabetes, suggesting that diabetes low serum magnesium status is osmotic diuresis-dependent. To assess the relationship between serum magnesium and HDL-cholesterol concentration adjusted by serum glucose values. We assessed th...

journal_title：Journal of diabetes and its complications

authors： Guerrero-Romero F,Rodríguez-Morán M

更新日期：2000-09-01 00:00:00

abstract：:We have investigated whether gliclazide, a second-generation sulfonylurea hypoglycemic agent, interferes with the impairment of endothelium-dependent nitric-oxide-mediated relaxation produced by 14%-glycosylated human oxyhemoglobin (GHHb). For comparative purposes, other agents, like glibenclamide, aminoguanidine, asc...

journal_title：Journal of diabetes and its complications

authors： Vallejo S,Angulo J,Peiró C,Sánchez-Ferrer A,Cercas E,Nevado J,Sánchez-Ferrer CF,Rodríguez-Mañas L

更新日期：2000-07-01 00:00:00

abstract：:We have recently shown that the net release of tissue-type plasminogen activator (t-PA) antigen can be rapidly enhanced by the muscarinic receptor stimulation in healthy males. Since diabetes mellitus has been associated with endothelial dysfunction, the aim of the present study was to compare the endothelium-derived ...

journal_title：Journal of diabetes and its complications

authors： Manhem K,Dotevall A,Wilhelmsen L,Jern S

更新日期：2000-05-01 00:00:00

abstract：:Hypertension and diabetes mellitus are independently associated with a high rate of target organ complications, which is particularly accentuated in the Negroid race. The aims of this study were to evaluate the mortality associated with diabetes mellitus and concurrent hypertension and diabetes mellitus in indigenous ...

journal_title：Journal of diabetes and its complications

authors： Kolawole BA,Ajayi AA

更新日期：2000-03-01 00:00:00

abstract：:The aim was to evaluate the relative importance of an established battery of five function tests used in the assessment of cardiovascular autonomic neuropathy (CAN) in diabetes employing spectral analysis of heart rate variability (HRV) as the reference test. In a population-based sample of 178 diabetic persons and 19...

journal_title：Journal of diabetes and its complications

authors： May O,Arildsen H

更新日期：2000-01-01 00:00:00

abstract：:To investigate whether the two free-radical scavengers, Cu, Zn- and Mn-superoxide dismutase (SOD), are changed in leukocytes of diabetic patients, and the alteration of these enzymes correlates with the diabetic state, we measured the activity and concentration of these enzymes in leukocytes from diabetic patients. Bo...

journal_title：Journal of diabetes and its complications

authors： Uchimura K,Nagasaka A,Hayashi R,Makino M,Nagata M,Kakizawa H,Kobayashi T,Fujiwara K,Kato T,Iwase K,Shinohara R,Kato K,Itoh M

更新日期：1999-09-01 00:00:00

abstract：:The study investigated the prevalence of incipient renal dysfunction in two cohorts with identical duration of type I diabetes but with childhood or adult onset of the disease. The pattern of glomerular (albumin, alb) and tubular (alpha(1)-microglobulin, alpha(1)-m, and N-acetyl-beta-D-glucosaminidase, NAG) urinary pr...

journal_title：Journal of diabetes and its complications

authors： Kordonouri O,Kahl A,Jörres A,Hopfenmüller W,Müller C,Danne T

更新日期：1999-09-01 00:00:00

abstract：:Tamm-Horsfall protein (THP), a glycoprotein produced in the thick ascending limb (TAL) and the early distal convoluted tubule (DCT), is normally excreted in large amounts in urine. Urinary THP may be a useful marker for renal damage. The goal of this research project was to determine the THP excretion in control and d...

journal_title：Journal of diabetes and its complications

authors： Below AA,Chakraborty J,Khuder SH,Haselhuhn GD

更新日期：1999-07-01 00:00:00

abstract：:In order to determine the local prevalence of polyneuropathy among adult outpatients with type II (non-insulin-dependent) diabetes mellitus, we applied a series of standardised measures to patients attending a multidisciplinary diabetes clinic. The study group comprised 94 men and 15 women; mean age, 70.6+/-7.8 years;...

journal_title：Journal of diabetes and its complications

authors： de Wytt CN,Jackson RV,Hockings GI,Joyner JM,Strakosch CR

更新日期：1999-03-01 00:00:00

abstract：:Currently, neither the American Diabetes Association nor the Kidney Foundation consider the results of a positive dipstick urine test for protein, a semi-quantitative measurement, in the final evaluation of diabetic nephropathy. Instead, they require a quantitative test. The object of this study was to assess whether ...

journal_title：Journal of diabetes and its complications

authors： Davidson MB,Smiley JF

更新日期：1999-01-01 00:00:00